Lexus.
After much research I bought an '07 GS350 to DD. It had 100k miles when I purchased the car in Aug of 2017, and have 165k on it now. I was skeptical, but aside from oil changes, it's only needed brake pads and a new battery. Also, they don't fall apart at 100 mph -- that is nonsense. I'd buy another Lex in a heartbeat.
Lexus infotainment is definitely behind the Germans -- as are most Asian and American brands. If that's a deal breaker, lease a new Audi, they are cool cars. I wouldn't recommend buying a pre-owned one though. A close friend of mine bought a used A4. He got rid of it recently and vowed to never own another one.
I have an '06 GS430, the last of the GS V8's. I bought it about a year ago, it was owned by a retired surgeon. One owner, 52K miles and all dealer serviced. Car is a tank, Lexus build quality has gone down but still rivals most Euro cars.