I have first hand experience with this on my 2013.
It will be perfectly fine.
The new 5.0's run off an actual wideband to the ecu. It makes adjustments very accurately and will compensate just fine for the LT's. I ran my LT's with catless mids for over a month before I tuned it. I even put it on the dyno and it ran stock AFR at WOT. The wideband kept the fuel trims in line and didn't let it run lean or rich.
It is highly recommended to tune, obviously, but the ECU will learn the LT's.
I've had a couple very reputable tunes and have tuned it myself with HP Tuners as well.
Nothing to fear as long as the O2 sensors are all working.
Good luck with the Long Tube install! it was a PITA for me lol.
::EDIT:: Here is my thread for reference....
http://www.s197forum.com/forum/showthread.php?t=111564
Awesome information, it would be great if GM did this as well
Actually, they did lol.
My 2009 Cobalt SS Turbo had a factory wideband. Was awesome to tune and got gobbs of power from very basic stuff. Ran12.8 on all season street tires. I miss that car.